SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

Schedule 13G

Under the Securities Exchange Act of 1934

(Amendment No. 1)*

Opexa Therapeutics, Inc.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

68372T103

(CUSIP Number)

December 31, 2012

(Date of Event Which Requires Filing of this Statement)

CUSIP No.			68372T103
1) Name of Reporting Person			Lehman Brothers Holdings Inc.
S.S. or I.R.S. Identification No. of Above Person			13-3216325
2)  Check the Appropriate Box if a Member of a Group			(a)  [   ]
			(b)  [   ]
3)  SEC Use Only
4)  Citizenship or Place of Organization			Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:
	5) Sole Voting Power				-0-
	6) Shared Voting Power				-0-
	7) Sole Dispositive Power				-0-
	8) Shared Dispositive Power				-0-
9)  Aggregate Amount Beneficially Owned by Each Reporting Person				-0-
10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares				[   ]
11)  Percent of Class Represented by Amount in Row 9				0%
12)  Type of Reporting Person				HC/CO

CUSIP No.			68372T103
1) Name of Reporting Person			Lehman ALI Inc.
S.S. or I.R.S. Identification No. of Above Person			13-3695935
2)  Check the Appropriate Box if a Member of a Group			(a)  [   ]
			(b)  [   ]
3)  SEC Use Only
4)  Citizenship or Place of Organization			Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:
	5) Sole Voting Power				-0-
	6) Shared Voting Power				-0-
	7) Sole Dispositive Power				-0-
	8) Shared Dispositive Power				-0-
9)  Aggregate Amount Beneficially Owned by Each Reporting Person				-0-
10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares				[   ]
11)  Percent of Class Represented by Amount in Row 9				0%
12)  Type of Reporting Person				CO

CUSIP No.			68372T103
1) Name of Reporting Person			LB I Group Inc.
S.S. or I.R.S. Identification No. of Above Person			13-2741778
2)  Check the Appropriate Box if a Member of a Group			(a)  [   ]
			(b)  [   ]
3)  SEC Use Only
4)  Citizenship or Place of Organization			Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:
	5) Sole Voting Power				-0-
	6) Shared Voting Power				-0-
	7) Sole Dispositive Power				-0-
	8) Shared Dispositive Power				-0-
9)  Aggregate Amount Beneficially Owned by Each Reporting Person				-0-
10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares				[   ]
11)  Percent of Class Represented by Amount in Row 9				0%
12)  Type of Reporting Person				CO

 

 

Item 1(a).		Name of Issuer:
		Opexa Therapeutics, Inc. (the “Issuer”)
Item 1(b).		Address of Issuer’s Principal Executive Offices:
		2635 Technology Forest Blvd. The Woodlands, TX 77381
Item 2(a).		Name of Person(s) Filing:
		Lehman Brothers Holdings Inc. (“Holdings”)
		Lehman ALI Inc. (“Lehman ALI”)
		LB I Group Inc. (“LB I Group”)
		On September 19, 2008, the Securities Investor Protection Corporation under the Securities Investor Protection Act, as amended (“SIPA”) commenced a proceeding against Lehman Brothers Inc. (“LBI”) in the United States District Court for the Southern District of New York (the “District Court”) in the case captioned Securities Investors Protection Corporation v. Lehman Brothers Inc., Case No. 08-CIV-8119 (GEL).  On September 19, 2008, the District Court entered the Order commencing Liquidation (the “LBI Liquidation Order”) pursuant to the provisions of SIPA.  The LBI Liquidation order provided, among other things, the appointment of James W. Giddens as trustee for the SIPA liquidation and removed the proceeding to the Bankruptcy Court under Case No. 08-1420 (JMP) SIPA.  As a result, LBI is no longer an affiliate of Holdings and Holdings can no longer be deemed to be the beneficial owner of any shares of the Issuer’s Common Stock that may or may not be owned by LBI.  In addition, on September 19, 2008, LBI transferred its entire ownership interest in LB I Group to Lehman ALI.  LBI is, therefore, no longer a Reporting Person.
Item 2(b).		Address of Principal Business Office:
		Lehman Brothers Holdings Inc. 1271 Avenue of the Americas New York, New York 10020
		Lehman ALI Inc. c/o Lehman Brothers Holdings Inc. 1271 Avenue of the Americas New York, New York 10020

		LB I Group Inc.
		c/o Lehman Brothers Holdings Inc.
		1271 Avenue of the Americas
		New York, New York 10020
Item 2(c).		Citizenship or Place of Organization:
		Holdings is a corporation organized under the laws of the State of Delaware.
		Lehman ALI is a corporation organized under the laws of the State of Delaware.
		LB I Group is a corporation organized under the laws of the State of Delaware.
Item 2(d).		Title of Class of Securities:
		Common Stock
Item 2(e).		CUSIP Number:
		68372T103
Item 3.		If this statement is filed pursuant to Rules 13d-1(b) or 13d-2(b) or (c), check whether the person filing is a:
		(a)	[   ]	A broker or dealer under Section 15 of the 1934 Act
		(b)	[   ]	A bank as defined in Section 3(a)(6) of the 1934 Act
		(c)	[   ]	An insurance company as defined in Section 3(a) (19) of the 1934 Act
		(d)	[   ]	An investment company registered under Section 8 of the Investment Company Act of 1940
		(e)	[   ]	An investment advisor in accordance with Rule 13d-1(b)(1)(ii)(E)
		(f)	[   ]	An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F)
		(g)	[   ]	A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G)
		(h)	[   ]	A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act
		(i)	[   ]	A church plan that is excluded from the definition of investment Company under Section 3(c)(14) of the Investment Company Act Of 1940
		(j)	[   ]	A group, in accordance with Rule 13d-1(b)(1)(ii)(J)

Item 4.		Ownership

(a)	Amount Beneficially Owned:
	See Item 9 of cover pages.
(b)	Percent of Class:
	See Item 11 of cover pages.
(c)	Number of shares as to which the person has:
	(i)    sole power to vote or to direct the vote
	(ii)   shared power to vote or to direct the vote
	(iii)  sole power to dispose or to direct the disposition
	(iv)  shared power to dispose or to direct the disposition